| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Bvf Inc | 4.37M (12.52%) | 4.37M Increased by +100.00% | Sep 30, 23 |
| 2 | Eventide Asset Management, LLC | 3.96M (11.35%) | 499.38K Increased by +12.62% | Sep 30, 23 |
| 3 | NEA Management Company, LLC | 2.19M (6.27%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 4 | BlackRock Inc | 2.11M (6.06%) | 83.03K Increased by +3.93% | Sep 30, 23 |
| 5 | HHG PLC | 1.92M (5.51%) | 1.66M Increased by +86.19% | Sep 30, 23 |
| 6 | Rock Springs Capital Management LP | 1.82M (5.22%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 7 | Citadel Advisors Llc | 1.72M (4.92%) | 287.41K Increased by +16.74% | Sep 30, 23 |
| 8 | Vanguard Group Inc | 1.69M (4.85%) | 98.69K Increased by +5.83% | Sep 30, 23 |
| 9 | State Street Corporation | 1.62M (4.65%) | 126.49K Increased by +7.80% | Sep 30, 23 |
| 10 | Novo A/S | 1.50M (4.30%) | -184.19K Decreased by -12.28% | Sep 30, 23 |
| 11 | Cadian Capital Management LP | 1.43M (4.11%) | 170.00K Increased by +11.85% | Sep 30, 23 |
| 12 | Wagonhound Investments, LP | 1.20M (3.44%) | 284.25K Increased by +23.70% | Sep 30, 23 |
| 13 | Polar Capital Holdings PLC | 1.18M (3.37%) | 250.00K Increased by +21.28% | Sep 30, 23 |
| 14 | Avidity Partners Management LP | 1.14M (3.28%) | 1.14M Increased by +100.00% | Sep 30, 23 |
| 15 | TANG CAPITAL MANAGEMENT LLC | 1.14M (3.26%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 16 | Franklin Resources Inc | 744.62K (2.13%) | 133.54K Increased by +17.93% | Sep 30, 23 |
| 17 | Pictet Asset Manangement SA | 739.01K (2.12%) | 739.01K Increased by +100.00% | Sep 30, 23 |
| 18 | Perceptive Advisors LLC | 672.04K (1.93%) | 70.48K Increased by +10.49% | Sep 30, 23 |
| 19 | Adage Capital Partners Gp LLC | 665.00K (1.91%) | 665.00K Increased by +100.00% | Sep 30, 23 |
| 20 | AXA SA | 617.12K (1.77%) | -51.76K Decreased by -8.39% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Eventide Healthcare & Life Sciences I | 2.33M (6.68%) | 269.87K Increased by +11.59% | Sep 30, 23 |
| 2 | Eventide Gilead N | 1.63M (4.67%) | 228.57K Increased by +14.04% | Sep 30, 23 |
| 3 | SPDR® S&P Biotech ETF | 1.16M (3.31%) | -6.70K Decreased by -0.58% | Dec 31, 23 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 1.04M (2.97%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 5 | Polar Capital Biotech S Inc | 850.00K (2.44%) | -119.27K Decreased by -14.03% | Nov 30, 23 |
| 6 | MEDICAL BioHealth EUR Acc | 756.50K (2.17%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 7 | iShares Russell 2000 ETF | 655.46K (1.88%) | 4.17K Increased by +0.64% | Dec 29, 23 |
| 8 | Franklin Biotechnology Discv A(acc)USD | 533.51K (1.53%) | 25.60K Increased by +4.80% | Nov 30, 23 |
| 9 | Vanguard Institutional Extnd Mkt Idx Tr | 460.24K (1.32%) | 939.00 Increased by +0.20% | Nov 30, 23 |
| 10 | Pictet-Biotech P USD | 425.52K (1.22%) | 1.44K Increased by +0.34% | Jun 30, 23 |
| 11 | Janus Henderson Global Life Sciences | 421.84K (1.21%) | 421.84K Increased by +100.00% | Sep 30, 23 |
| 12 | Janus Henderson Global Life Sciences D | 421.84K (1.21%) | 421.84K Increased by +100.00% | Sep 30, 23 |
| 13 | Janus Henderson Glb Life Scn I2 USD | 334.17K (0.96%) | 5.73K Increased by +1.72% | Nov 30, 23 |
| 14 | AXA Framlington Health R Inc | 333.64K (0.96%) | -10.12K Decreased by -3.03% | Nov 30, 23 |
| 15 | Janus Selection Global Life Science AUSD | 328.92K (0.94%) | 328.92K Increased by +100.00% | Sep 30, 23 |
| 16 | Janus Henderson US Small Cap Growth | 308.19K (0.88%) | 308.19K Increased by +100.00% | Sep 30, 23 |
| 17 | Janus Henderson Venture D | 308.19K (0.88%) | 308.19K Increased by +100.00% | Sep 30, 23 |
| 18 | Pictet-Global Megatrend Sel I USD | 306.57K (0.88%) | -1.21K Decreased by -0.39% | Jun 30, 23 |
| 19 | UTM IM GBP AXA Framlington Biotech | 262.15K (0.75%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 20 | APO Medical Opportunities R | 260.80K (0.75%) | 0.00 Increased by 0.00% | Nov 30, 23 |