| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 46.20M (9.31%) | 14.66M Increased by +31.72% | Sep 30, 23 |
| 2 | BlackRock Inc | 37.16M (7.49%) | 1.18M Increased by +3.18% | Sep 30, 23 |
| 3 | Vanguard Group Inc | 26.65M (5.37%) | -32.99K Decreased by -0.12% | Sep 30, 23 |
| 4 | Deep Track Capital, LP | 25.70M (5.18%) | 1.53M Increased by +5.95% | Sep 30, 23 |
| 5 | State Street Corporation | 25.37M (5.11%) | 4.09M Increased by +16.13% | Sep 30, 23 |
| 6 | TCG Crossover Management, LLC | 23.38M (4.71%) | -213.94K Decreased by -0.92% | Sep 30, 23 |
| 7 | NEA Management Company, LLC | 22.78M (4.59%) | 1.43M Increased by +6.27% | Sep 30, 23 |
| 8 | Vivo Capital, LLC | 16.52M (3.33%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 9 | Millennium Management LLC | 16.07M (3.24%) | 3.86M Increased by +24.05% | Sep 30, 23 |
| 10 | MPM Oncology Impact Management LP | 10.71M (2.16%) | 1.52M Increased by +14.20% | Sep 30, 23 |
| 11 | Wellington Management Company LLP | 10.41M (2.10%) | 342.49K Increased by +3.29% | Sep 30, 23 |
| 12 | Geode Capital Management, LLC | 10.01M (2.02%) | 697.50K Increased by +6.97% | Sep 30, 23 |
| 13 | FMR Inc | 7.56M (1.52%) | -342.97K Decreased by -4.54% | Sep 30, 23 |
| 14 | Marshall Wace Asset Management Ltd | 5.86M (1.18%) | -3.95M Decreased by -67.39% | Sep 30, 23 |
| 15 | Artal Group S A | 5.57M (1.12%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 16 | Northern Trust Corp | 5.36M (1.08%) | 133.05K Increased by +2.48% | Sep 30, 23 |
| 17 | Segall Bryant & Hamill | 4.99M (1.01%) | 1.55M Increased by +30.97% | Sep 30, 23 |
| 18 | Amvescap Plc. | 4.56M (0.92%) | 784.82K Increased by +17.22% | Sep 30, 23 |
| 19 | Sofinnova Ventures | 3.70M (0.75%) | -1.73M Decreased by -46.63% | Sep 30, 23 |
| 20 | Charles Schwab Investment Management Inc | 3.63M (0.73%) | 2.30M Increased by +63.29% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 16.29M (3.28%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 2 | SPDR® S&P Biotech ETF | 14.81M (2.98%) | -85.77K Decreased by -0.58% | Dec 31, 23 |
| 3 | iShares Russell 2000 ETF | 13.64M (2.75%) | 86.77K Increased by +0.64% | Dec 29, 23 |
| 4 | Vanguard Institutional Extnd Mkt Idx Tr | 6.55M (1.32%) | 144.53K Increased by +2.21% | Nov 30, 23 |
| 5 | Fidelity® Small Cap Index | 4.81M (0.97%) | 131.18K Increased by +2.73% | Oct 31, 23 |
| 6 | Invesco Pharmaceuticals ETF | 4.14M (0.83%) | 0.00 Increased by 0.00% | Dec 29, 23 |
| 7 | iShares Russell 2000 Growth ETF | 3.43M (0.69%) | 0.00 Increased by 0.00% | Dec 29, 23 |
| 8 | iShares Biotechnology ETF | 3.42M (0.69%) | -3.12K Decreased by -0.09% | Dec 29, 23 |
| 9 | State St Russell Sm/Mid Cp® Indx NL Cl C | 3.03M (0.61%) | 194.60K Increased by +6.42% | Dec 31, 23 |
| 10 | Fidelity® Select Biotechnology | 2.95M (0.59%) | -257.60K Decreased by -8.74% | Nov 30, 23 |
| 11 | Fidelity® Extended Market Index | 2.47M (0.50%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 12 | Schwab US Small-Cap ETF™ | 2.17M (0.44%) | 972.00 Increased by +0.04% | Dec 30, 23 |
| 13 | Fidelity Growth Compy Commingled Pl O | 1.94M (0.39%) | 12.14K Increased by +0.63% | Nov 30, 23 |
| 14 | State St Russell Sm Cap® Indx SL Cl I | 1.84M (0.37%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 15 | Direxion Daily S&P Biotech Bull 3X ETF | 1.78M (0.36%) | 65.06K Increased by +3.66% | Dec 28, 23 |
| 16 | Vanguard Russell 2000 ETF | 1.54M (0.31%) | 29.46K Increased by +1.92% | Nov 30, 23 |
| 17 | NT R2000 Index Fund - NL | 1.44M (0.29%) | 21.99K Increased by +1.53% | Sep 30, 23 |
| 18 | Vanguard Health Care ETF | 1.33M (0.27%) | 1.33M Increased by +100.00% | Nov 30, 23 |
| 19 | MEDICAL BioHealth EUR Acc | 1.29M (0.26%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 20 | iShares Russell 2000 Value ETF | 1.25M (0.25%) | 2.33K Increased by +0.19% | Dec 29, 23 |